Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5319)
Drug Name
Efinaconazole
Synonyms IDP-108; KP-103
Indication Fungal infection [ICD11: 1F29-1F2F] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 348.4 Topological Polar Surface Area 54.2
Heavy Atom Count 25 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
489181
ChEBI ID
CHEBI:82718
CAS Number
164650-44-6
TTD Drug ID
D0G4BI
Formula
C18H22F2N4O
Canonical SMILES
C[C@H]([C@](CN1C=NC=N1)(C2=C(C=C(C=C2)F)F)O)N3CCC(=C)CC3
InChI
InChI=1S/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/m1/s1
InChIKey
NFEZZTICAUWDHU-RDTXWAMCSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
UK-215,364 DM005290
6426669
Unclear - Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010837 Efinaconazole Efinaconazole H3 Unclear - Unclear Unclear [2]
References
1 Efinaconazole: Developmental and reproductive toxicity potential of a novel antifungal azole. Reprod Toxicol. 2015 Apr;52:18-25.
2 Safety and pharmacokinetics of efinaconazole 10% solution in healthy volunteers and patients with severe onychomycosis

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