Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5346)
Drug Name
Imidapril
Prodrug Info Imidapril is the prodrug of Imidaprilat
Synonyms Tanatil (TN)
Indication Cardiovascular disease [ICD11: BA00-BE2Z] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 405.4 Topological Polar Surface Area 116
Heavy Atom Count 29 Rotatable Bond Count 10
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
5464343
CAS Number
1-37-9
TTD Drug ID
D0S0ES
Formula
C20H27N3O6
Canonical SMILES
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@@H](CN(C2=O)C)C(=O)O
InChI
InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1
InChIKey
KLZWOWYOHUKJIG-BPUTZDHNSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Imidapril Metabolite M2 DM015851
13852999
Unclear - Unclear 1 [2]
Imidapril Metabolite M3 DM015416
3769726
Unclear - Unclear 1 [3]
Imidaprilat DM006010
5464344
Unclear - Unclear 1 [4]
Imidapril Metabolite M2 DM015851
13852999
Unclear - Unclear 2 [4]
Imidapril Metabolite M4 DM015817
13044284
Unclear - Unclear 2 [3]
Imidapril Metabolite M4 DM015817
13044284
Unclear - Unclear 2 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR008709 Imidapril Imidaprilat Unclear - Unclear CES1 [4]
MR008712 Imidapril Imidapril Metabolite M3 Unclear - Unclear Unclear [3]
MR008714 Imidapril Imidapril Metabolite M2 Unclear - Unclear Unclear [2]
MR008713 Imidapril Metabolite M3 Imidapril Metabolite M4 Unclear - Unclear Unclear [3]
MR008710 Imidaprilat Imidapril Metabolite M4 Unclear - Unclear Unclear [4]
MR008711 Imidaprilat Imidapril Metabolite M2 Unclear - Unclear Unclear [4]
⏷ Show the Full List of 6 MR(s)
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 7th communication: in vitro metabolism
3 Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 5th communication: isolation and identification of metabolites of imidapril in rats, dogs, and monkeys
4 Radioimmunoassay for imidapril, a new angiotensin-converting enzyme inhibitor, and imidaprilat, its active metabolite, in human plasma and urine

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