Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5431)
Drug Name
Dextrothyroxine Sodium
Synonyms Choloxin
Indication Hypertriglyceridaemia [ICD11: 5C80] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 798.85 Topological Polar Surface Area 95.6
Heavy Atom Count 25 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
23690433
CAS Number
137-53-1
TTD Drug ID
D03TPR
Formula
C15H10I4NNaO4
Canonical SMILES
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@H](C(=O)[O-])N.[Na+]
InChI
InChI=1S/C15H11I4NO4.Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;/h1-2,4-5,12,21H,3,20H2,(H,22,23);/q;+1/p-1/t12-;/m1./s1
InChIKey
YDTFRJLNMPSCFM-UTONKHPSSA-M
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Levothyroxine sulfate DM000316
131742
Unclear - Unclear 1 [2]
Thyroxine glucuronide DM015202
152424
Unclear - Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010707 Dextrothyroxine Sodium Thyroxine sulfate Unclear - Unclear Unclear [2]
MR010708 Dextrothyroxine Sodium Thyroxine glucuronide Unclear - Unclear Unclear [2]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 DrugBank(Pharmacology-Metabolism):Dextrothyroxine Sodium

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.