Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0342)
Drug Name
Clobazam
Synonyms
Chlorepin; Clobazam; Clobazamum; Clobazamum [INN-Latin]; Clorepin; Frisium; LM 2717; LM-2717; RU-4723; Urbadan; Urbanyl; 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine; 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl-; 22316-47-8; 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione; 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione; BRN 0758410; CCRIS 7506; EINECS 244-908-7; H 4723; H-4723; HR 376; NSC 336279; Onfi; UNII-2MRO291B4U
Indication Lennox-Gastaut syndrome [ICD11: 8A62] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 300.74 Topological Polar Surface Area 40.6
Heavy Atom Count 21 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
2789
ChEBI ID
CHEBI:31413
CAS Number
22316-47-8
TTD Drug ID
D0S9MC
Formula
C16H13ClN2O2
Canonical SMILES
CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
InChI
1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
InChIKey
CXOXHMZGEKVPMT-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Clobazam Metabolite M4 DM006081
156028120
Unclear 1 [4]
Clobazam Metabolite M7 DM006080
14275474
Unclear 1 [4]
Clobazam Metabolite M9 DM006075
89657
Unclear 1 [4] , [2]
Clobazam Metabolite M10 DM006079
12624864
Unclear 2 [4]
Clobazam Metabolite M3 DM006076
155928913
Unclear 2 [4]
Clobazam Metabolite M5 DM006078
14275476
Unclear 2 [4]
Clobazam Metabolite M8 DM006082 N. A. Unclear 2 [4]
Clobazam Metabolite M6 DM006077 N. A. Unclear 3 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006541 Clobazam Clobazam Metabolite M9 Unclear CYP2B6 ... [4], [2]
MR006546 Clobazam Clobazam Metabolite M7 Unclear CYP2C18 ... [4]
MR006548 Clobazam Clobazam Metabolite M4 Unclear Unclear [4]
MR006549 Clobazam Metabolite M4 Clobazam Metabolite M8 Unclear Unclear [4]
MR006547 Clobazam Metabolite M7 Clobazam Metabolite M5 Unclear CYP2B6 ... [4]
MR006542 Clobazam Metabolite M9 Clobazam Metabolite M3 Unclear Unclear [4]
MR006544 Clobazam Metabolite M9 Clobazam Metabolite M5 Unclear CYP2C18 ... [4]
MR006545 Clobazam Metabolite M9 Clobazam Metabolite M10 Unclear Unclear [4]
MR006543 Clobazam Metabolite M3 Clobazam Metabolite M6 Unclear Unclear [4]
⏷ Show the Full List of 9 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2B6 (CYP2B6) DME0020 Homo sapiens
CP2B6_HUMAN
1.14.14.1
[2]
Cytochrome P450 2C18 (CYP2C18) DME0017 Homo sapiens
CP2CI_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Homo sapiens
CP2CJ_HUMAN
1.14.14.1
[3]
References
1 Clobazam was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86.
3 A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam. Brain Dev. 2004 Dec;26(8):530-4.
4 Kinetics and metabolism of clobazam in animals and man

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