Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0749)
Drug Name
Fosfomycin
Synonyms
Fosfocina; Fosfomicina; Fosfomycin sodium; Fosfomycine; Fosfomycinum; Fosfonomycin; Phosphomycin disodium salt; Phosphonemycin; Phosphonomycin; Veramina; YMDXZJFXQJVXBF-STHAYSLISA-N; phosphomycin; (2R-cis)-(3-Methyloxiranyl)phosphonic acid; 1,2-EPOXYPROPYLPHOSPHONIC ACID; 23155-02-4; CHEBI:28915; CHEMBL1757; FCN; Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)-; Antibiotic 833A; FOSFOMYCIN; Phosphonicacid, P-[(2R,3S)-3-methyl-2-oxiranyl]-; UNII-2N81MY12TE; [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
Indication Infectious cystitis [ICD11: GC00] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 138.06 Topological Polar Surface Area 70.1
Heavy Atom Count 8 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
446987
PubChem SID
8687 ; 606108 ; 7887444 ; 8013956 ; 8027671 ; 10299988 ; 14747737 ; 15297304 ; 36889264 ; 46506665 ; 47206194 ; 50126493 ; 50767051 ; 57404778 ; 92298260 ; 93166606 ; 96099807 ; 103707732 ; 103934869 ; 104637332 ; 116933583 ; 124349057 ; 124385179 ; 129815629 ; 134338052 ; 134994616 ; 137006369 ; 140608615 ; 142971088 ; 160658318 ; 160964170 ; 162008097 ; 162496683 ; 164187510 ; 164187514 ; 164187516 ; 164187519 ; 164187529 ; 174551524 ; 175266349 ; 179150196 ; 226434285 ; 241044746 ; 250133924
ChEBI ID
CHEBI:28915
CAS Number
23155-02-4
TTD Drug ID
D01GYT
Formula
C3H7O4P
Canonical SMILES
CC1C(O1)P(=O)(O)O
InChI
1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1
InChIKey
YMDXZJFXQJVXBF-STHAYSLISA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Glutathione S-transferase alpha-1 (GSTA1) DME0011 Homo sapiens
GSTA1_HUMAN
2.5.1.18
[2]
References
1 Fosfomycin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria. Antimicrob Agents Chemother. 1988 Oct;32(10):1552-6.

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