Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1215)
Drug Name
Oxiconazole
Synonyms
Oxiconazol; Oxiconazol [INN-Spanish]; Oxiconazole (INN); Oxiconazole [INN:BAN]; Oxiconazolum; Oxiconazolum [INN-Latin]; Oxizole; RO-13-8996; Ro 13-8996; oxiconazole; oxyconazole; 2',4'-Dichlor-O-(2,4-dichlorbenzyl)-2-(1-imidazolyl)-(Z)-acetophenonoxim; 2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-(O-(2,4-dichlorobenzyl)oxime); 64211-45-6; C18H13Cl4N3O; C668Q9I33J; CHEBI:7825; Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime, (Z)-; UNII-C668Q9I33J
Indication Dermatophytosis [ICD11: 1F28] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 429.1 Topological Polar Surface Area 39.4
Heavy Atom Count 26 Rotatable Bond Count 6
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
5353853
PubChem SID
10274 ; 7980217 ; 14807454 ; 24591563 ; 39379767 ; 48319955 ; 50065009 ; 50122564 ; 50990349 ; 57361598 ; 71822671 ; 85787428 ; 92309111 ; 92711924 ; 93166843 ; 96025000 ; 103388855 ; 113909788 ; 124766357 ; 125312381 ; 126630392 ; 126685558 ; 134338444 ; 134609034 ; 135047656 ; 142043571 ; 152046181 ; 162175084 ; 172080024 ; 172861933 ; 175267699 ; 176484428 ; 179150842 ; 179225149 ; 223440376 ; 223555547 ; 223677529 ; 226420967 ; 230460673 ; 241114901 ; 252358864
ChEBI ID
CHEBI:7825
CAS Number
64211-46-7
TTD Drug ID
D04GYO
Formula
C18H13Cl4N3O
Canonical SMILES
C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
InChI
1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18+
InChIKey
QRJJEGAJXVEBNE-HKOYGPOVSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Homo sapiens
CP2CJ_HUMAN
1.14.14.1
[2]
References
1 Oxiconazole was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite. Drug Metab Dispos. 2011 Apr;39(4):693-702.

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