Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1927)
Drug Name
SQ-32709
Synonyms
Sq 32709; all-trans-Farnesyl pyrophosphate; farnesyl diphosphate; farnesyl pyrophosphate; farnesyl-PP; trans,trans-Farnesyl diphosphate; trans-Farnesyl pyrophosphate; trans-trans-farnesyl diphosphate; (2E,6E)-Farnesyl diphosphate; (2E,6E)-Farnesyl pyrophosphate; (E,E)-Farnesyl diphosphate; (E,E)-Farnesyl pyrophosphate; (all-E)-Farnesyl diphosphate; 2-trans,6-trans-Farnesyl pyrophosphate; 2-trans,6-trans-farnesyl diphosphate; CHEBI:17407; CHEMBL69330; UNII-79W6B01D07; trans,trans-Farnesyl pyrophosphate
Indication Arteriosclerosis obliterans [ICD11: BD40] Discontinued [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 382.33 Topological Polar Surface Area 113
Heavy Atom Count 24 Rotatable Bond Count 11
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
445713
ChEBI ID
CHEBI:17407
CAS Number
372-97-4
TTD Drug ID
D0N5HO
Formula
C15H28O7P2
Canonical SMILES
CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C
InChI
1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
InChIKey
VWFJDQUYCIWHTN-YFVJMOTDSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Ras proteins prenyltransferase alpha (FNTA) DME0575 Homo sapiens
FNTA_HUMAN
2.5.1.58
[2]
Squalene synthase (FDFT1) DME0571 Homo sapiens
FDFT_HUMAN
2.5.1.21
[3]
References
1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005302)
2 Site-selective enzymatic labeling of designed ankyrin repeat proteins using protein farnesyltransferase. Methods Mol Biol. 2019;2033:207-219.
3 Increased activity of the sterol branch of the mevalonate pathway elevates glycosylation of secretory proteins and improves antifungal properties of Trichoderma atroviride. Fungal Genet Biol. 2020 Jan 17;137:103334.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.