Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2070)
Drug Name
Alpha-D-glucose
Synonyms
D-gluco-hexose; D-gluose; Glucopyranose, alpha-D-; a-D-Glucopyranose; alpha-D-Glucopyranose; alpha-Dextrose; alpha-glucose; glucoses; (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol; (2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; (2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetrol; .alpha.-D-Glucose; 492-62-6; 5J5I9EB41E; CHEBI:17925; CHEMBL423707; UNII-5J5I9EB41E; alpha-D(+)-Glucose, 99+%, anhydrous; alpha-D-Glc; alpha-D-glucose
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 180.16 Topological Polar Surface Area 110
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
79025
ChEBI ID
CHEBI:17925
CAS Number
492-62-6
Formula
C6H12O6
Canonical SMILES
C(C1C(C(C(C(O1)O)O)O)O)O
InChI
1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKey
WQZGKKKJIJFFOK-DVKNGEFBSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Alpha-D-glucose-6-phosphate DM001736
439284
Unclear 1 [3]
Beta-D-fructose 6-phosephate DM001737 N. A. Unclear 2 [3]
D-fructose 1,6-bisphosephate DM001738 N. A. Unclear 3 [3]
Triose phosphates DM001739 N. A. Unclear 4 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR000163 Alpha-D-glucose Alpha-D-glucose-6-phosphate Unclear Unclear [3]
MR000160 Alpha-D-glucose-6-phosphate Beta-D-fructose 6-phosephate Unclear Unclear [3]
MR000161 Beta-D-fructose 6-phosephate D-fructose 1,6-bisphosephate Unclear Unclear [3]
MR000162 D-fructose 1,6-bisphosephate Triose phosphates Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Galactose mutarotase (GALM) DME0513 Homo sapiens
GALM_HUMAN
5.1.3.3
[2]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Galactose mutarotase (GALM) DME0513 Km = 54 microM
GALM_HUMAN
[2]
References
1 MERCK database: alpha-D-Glucose.
2 Identification and characterisation of human aldose 1-epimerase. FEBS Lett. 2003 May 22;543(1-3):21-4.
3 Metabolism of D-glucose anomers in rat pancreatic islets exposed to equilibrated D-glucose Horm Metab Res. 2004 May;36(5):281-5. doi: 10.1055/s-2004-814481.

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