Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2099)
Drug Name
Glyoxylate
Synonyms Glyoxylat; HHLFWLYXYJOTON-UHFFFAOYSA-M; glyoxylate; oxaldehydate; oxoacetate; AC1MU8DW; CHEBI:36655; glyox
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 73.03 Topological Polar Surface Area 57.2
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
3614358
ChEBI ID
CHEBI:36655
CAS Number
298-12-4
Formula
C2HO3-
Canonical SMILES
C(=O)C(=O)[O-]
InChI
1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1
InChIKey
HHLFWLYXYJOTON-UHFFFAOYSA-M
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Glycine DM006517
750
Unclear 1 [2]
Glycolate DM006516
757
Unclear 1 [2]
Oxalate DM002325
71081
Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007013 Glyoxylate Glycolate Unclear GRHPR [2]
MR007014 Glyoxylate Oxalate Unclear Unclear [2]
MR007015 Glyoxylate Glycine Unclear GPT ... [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Alanine aminotransferase 1 (GPT) DME0531 Homo sapiens
ALAT1_HUMAN
2.6.1.2
[2]
Glyoxylate reductase/hydroxypyruvate reductase (GRHPR) DMEN343 Homo sapiens Not Available Not Available [2]
Phosphoserine aminotransferase (PSAT1) DME0532 Homo sapiens
SERC_HUMAN
2.6.1.52
[2]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Alanine aminotransferase 1 (GPT) DME0531 Km = 0.75 microM
ALAT1_HUMAN
[2]
Phosphoserine aminotransferase (PSAT1) DME0532 Km = 0.75 microM
SERC_HUMAN
[2]
References
1 Elektrolytische reduction von carbonsauren und carbonsaureestern in schwefelsaurer Losung. European Journal of Inorganic Chemistry. 1904;37(3):3187-3191.
2 Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism. Biochem J. 2009 Aug 13;422(2):265-72.

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