Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2251)
Drug Name
Ortho-phosphate
Synonyms
Acide phosphorique; Acide phosphorique [French]; Acido fosforico; Acido fosforico [Italian]; Acidum phosphoricum; Fosforzuuroplossingen; Fosforzuuroplossingen [Dutch]; ORTHOPHOSPHORIC ACID; POLYPHOSPHORIC ACID; Phosphoric acid; Phosphoric acid 75%; Phosphoric acid, ortho-; Phosphorsaeure; Phosphorsaeureloesungen; Phosphorsaeureloesungen [German]; Superphosphoric acid; Wc-reiniger; White phosphoric acid; o-Phosphoric acid; ortho-phosphoric acid; 7664-38-2; Caswell No. 662; Evits; FEMA No. 2900; Sonac; UNII-E4GA8884NN
Indication Thyroid cancer [ICD11: 2D10] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 97.995 Topological Polar Surface Area 77.8
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
1004
ChEBI ID
CHEBI:26078.
CAS Number
7664-38-2
Formula
H3O4P
Canonical SMILES
OP(=O)(O)O
InChI
1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Maltose phosphorylase (malP) DME1513 Lactobacillus brevis
A0A0C1MAP6_LACBR
2.4.1.8
[2]
References
1 ClinicalTrials.gov (NCT02880072) Absorption of Orally Ingested Phosphate in Refeeding Syndrome
2 Maltose phosphorylase from Lactobacillus brevis: purification, characterization, and application in a biosensor for ortho-phosphate. Enzyme Microb Technol. 1997 Nov 1;21(6):413-20.

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