Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2307)
Drug Name
Sulpiride
Synonyms
Sernevin; Splotin; Stamonevrol; Sulpirid; Sulpiridum [INN-Latin]; Sulpyrid; Suprium; Sursumid; Aiglonyl; Alimoral; Calmoflorine; Championyl; Coolspan; Darleton; Desmenat; Dobren; Dogmatil; Dogmatyl; Dolmatil; Dresent; Eglonil; Eglonyl; Enimon; Equilid; Eusulpid; Fardalan; Fidelan; Guastil; Isnamide; Kylistro; Lisopiride; Mariastel; Meresa; Miradol; Mirbanil; Misulvan; Neogama; Norestran; Normum; Nufarol; Omiryl; Omperan; Ozoderpin; Psicocen; Pyrkappl; Restful; Valirem; Zemorcon; sulpiride; (+/-)-Sulpiride; (RS)-(+/-)-sulpiride; 15676-16-1; Abilit
Indication Schizophrenia [ICD11: 6A20] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 341.4 Topological Polar Surface Area 110
Heavy Atom Count 23 Rotatable Bond Count 6
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
5355
ChEBI ID
CHEBI:32168
CAS Number
15676-16-1
Formula
C15H23N3O4S
Canonical SMILES
CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC
InChI
1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
InChIKey
BGRJTUBHPOOWDU-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
2-O-desmethyl sulpiride DM004885
129318232
Oxidation - O-demethylation 1 [3]
Sulmepride DM004886
3018598
Oxidation - N-demethylation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005265 Sulpiride 2-O-desmethyl sulpiride Oxidation - O-demethylation Unclear [3]
MR005266 Sulpiride Sulmepride Oxidation - N-demethylation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1251 Bacteroides fragilis Not Available Not Available [2]
References
1 Sulpiride. In: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD):National Library of Medicine (US); 2006.2018 Oct 31.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Studies on the distribution of 14C-sulpiride and its metabolites in the rat and guinea pig

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