Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2862)
Drug Name
Sulfacetamide
Synonyms
Sebizon; Steramide; Sulamyd; Sulf-10; Sulfacet; Sulfacetimide; Sulfacyl; Sulfanilacetamide; Sulfanilazetamid; Sulphacetamide; Sulphacetamidum; Sulphasil; Urosulfon; Urosulfone; p-Aminobenzenesulfonacetamide; sulfacetamide; 144-80-9; Acetocid; Acetosulfamin; Acetosulfamine; Albamine; Albucid; Alesten; Bleph-10; Formosulfacetamide; N-Acetylsulfanilamide; N-Sulfanilylacetamide; N-Sulphanilylacetamide; Oclucid; Region; N-((4-Aminophenyl)sulfonyl)acetamide; N-Acetyl-4-aminobenzenesulfonamide; N-[(4-Aminophenyl)sulfonyl]acetamide
Indication Seborrhoeic dermatitis [ICD11: EA81] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 214.24 Topological Polar Surface Area 97.6
Heavy Atom Count 14 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
5320
ChEBI ID
CHEBI:63845
CAS Number
144-80-9
Formula
C8H10N2O3S
Canonical SMILES
CC(=O)NS(=O)(=O)C1=CC=C(C=C1)N
InChI
1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
InChIKey
SKIVFJLNDNKQPD-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
N4-Acetylsulfanilamide DM006374
8482
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006845 Sulfacetamide N4-Acetylsulfanilamide Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1288 Shewanella oneidensis Not Available Not Available [2]
References
1 Sulfacetamide was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Biodegradation of sulfonamides by Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4. Biodegradation. 2018 Apr;29(2):129-140.
3 Broad-specificity immunoassays for sulfonamide detection: immunochemical strategy for generic antibodies and competitors

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