Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR3193)
Drug Name
Gabapentin enacarbil
Prodrug Info Gabapentin enacarbil is the prodrug of Alvocidib
Synonyms 1838262; ASP8825; Gabapentin-XP; GSK 1838262; Horizant; Regnite; Solzira; XP13512
Indication Alcohol dependence [ICD11: 6C40] Phase 2 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 329.39 Topological Polar Surface Area 102
Heavy Atom Count 23 Rotatable Bond Count 9
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
9883933
ChEBI ID
CHEBI:68840
CAS Number
478296-72-9
TTD Drug ID
D05KBU
Formula
C16H27NO6
Canonical SMILES
CC(C)C(=O)OC(C)OC(=O)NCC1(CCCCC1)CC(=O)O
InChI
InChI=1S/C16H27NO6/c1-11(2)14(20)22-12(3)23-15(21)17-10-16(9-13(18)19)7-5-4-6-8-16/h11-12H,4-10H2,1-3H3,(H,17,21)(H,18,19)
InChIKey
TZDUHAJSIBHXDL-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Alvocidib DM020042
5287969
Hydrolysis - Hydrolysis 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR014194 Gabapentin enacarbil Gabapentin Hydrolysis - Hydrolysis CES1 [2]
References
1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 FDA LABEL:Gabapentin enacarbil

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