Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5406)
Drug Name
Ampiroxicam
Synonyms Flucam; Nacyl; Nasil; CP-65703
Indication Inflammation [ICD11: 1A00-CA43] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 447.5 Topological Polar Surface Area 133
Heavy Atom Count 31 Rotatable Bond Count 8
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 9
Cross-matching ID
PubChem CID
2176
ChEBI ID
CHEBI:31210
CAS Number
99464-64-9
TTD Drug ID
D07OHO
Formula
C20H21N3O7S
Canonical SMILES
CCOC(=O)OC(C)OC1=C(N(S(=O)(=O)C2=CC=CC=C21)C)C(=O)NC3=CC=CC=N3
InChI
InChI=1S/C20H21N3O7S/c1-4-28-20(25)30-13(2)29-18-14-9-5-6-10-15(14)31(26,27)23(3)17(18)19(24)22-16-11-7-8-12-21-16/h5-13H,4H2,1-3H3,(H,21,22,24)
InChIKey
LSNWBKACGXCGAJ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Piroxicam DM016175
54676228
Unclear - Unclear 1 [2]
Benzothiazine metabolite DM002870
54676301
Unclear - Unclear 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR008909 Ampiroxicam Piroxicam Unclear - Unclear ES [2]
MR008910 Piroxicam 5'-Hydroxypiroxicam Unclear - Unclear CYP2C9 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2C9 (CYP2C9) DME0019 Homo sapiens
CP2C9_HUMAN
1.14.14.1
[2]
Esterases (ES) DMEN229 Homo sapiens Not Available Not Available [2]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Pharmacokinetic drug interactions between ampiroxicam and sulfaphenazole in rats

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