Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5419)
Drug Name
Penicillin V Potassium
Synonyms Ledercillin Vk; Pen-vee K; Pfizerpen Vk; Veetids; Veetids '125'; Veetids '250'; Uticillin Vk; Veetids '500'
Indication Bacterial infection [ICD11: 1A00-1C4Z] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 388.5 Topological Polar Surface Area 124
Heavy Atom Count 25 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
23676814
ChEBI ID
CHEBI:7967
CAS Number
132-98-9
TTD Drug ID
D02IIE
Formula
C16H17KN2O5S
Canonical SMILES
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)COC3=CC=CC=C3)C(=O)[O-])C.[K+]
InChI
InChI=1S/C16H18N2O5S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
InChIKey
HCTVWSOKIJULET-LQDWTQKMSA-M
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Penicilloic acid DM001188
52921568
Hydrolysis - Hydrolysis 1 [2] , [3]
Penicillin V Potassium metabolite 1 DM015808
12548074
Unclear 2 [3]
Penicillin V Potassium3 DM014982
19188
Unclear 2 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR013678 Penicillin V Potassium Penicilloic acid Hydrolysis - Hydrolysis OtLac [2], [3]
MR013679 Penicilloic acid Penicillin V Potassium metabolite 1 Unclear Unclear [3]
MR013680 Penicilloic acid Penicillin V Potassium3 Unclear Unclear [3]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Enzyme-catalyzed biodegradation of penicillin fermentation residues by -lactamase OtLac from Ochrobactrum tritici
3 Isolation and Characterization of Ochrobactrum tritici for Penicillin V Potassium Degradation

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