Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5770)
Drug Name
Proflavine
Synonyms
PRL; Proflavin; Proflavina; Proflavinum; Profura; Progarmed; Isoflav base; Proflavine [INN]; Proflavine hemisulfate; Proflavina [INN-Spanish]; Proflavine Hemi-Sulfate; Proflavinum [INN-Latin]; AE-562/12222295; Acridine-3,6-diamine; 2,8-Diaminoacridine; 2,8-Diaminoacridine (European); 2,8-Diaminoacridinium; 3,6-ACRIDINEDIAMINE; 3,6-Acridinediamine hydrochloride; 3,6-Diamino-acridinium; 3,6-Diaminoacridine; 3,6-Diaminoacridine sulfate; 3,6-Diaminoacridinium; 3,7-Diamino-5-azaanthracene
Indication Sepsis [ICD11: 1G40-1G41] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 209.25 Topological Polar Surface Area 64.9
Heavy Atom Count 16 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
7099
ChEBI ID
CHEBI:8452
CAS Number
92-62-6
TTD Drug ID
D08GSF
Formula
C13H11N3
Canonical SMILES
C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N
InChI
InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2
InChIKey
WDVSHHCDHLJJJR-UHFFFAOYSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Proflavine M1 PDM013795
12624266
Conjugation - N-Acetylation of arylamine 1 Human
Proflavine M2 PDM013796 N. A. Conjugation - Glucuronidation of primary aromatic amine 1 Human
References
1 Drug information of Proflavine, 2008. eduDrugs.

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