Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5792)
Drug Name
Migalastat
Synonyms DDIG; D-Galactitol, 1,5-dideoxy-1,5-imino; (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-iminogalactitol; 2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Indication Gaucher disease [ICD11: 5C56] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 163.17 Topological Polar Surface Area 93
Heavy Atom Count 11 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
176077
ChEBI ID
CHEBI:135923
CAS Number
108147-54-2
TTD Drug ID
D0MU9L
Formula
C6H13NO4
Canonical SMILES
C1[C@@H]([C@H]([C@H]([C@H](N1)CO)O)O)O
InChI
InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
InChIKey
LXBIFEVIBLOUGU-DPYQTVNSSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Migalastat M1 PDM013871 N. A. Conjugation - Alkyl-OH-glucuronidation 1 Human
Migalastat M2 PDM013872 N. A. Conjugation - Alkyl-OH-glucuronidation 1 Human
Migalastat M3 PDM013873 N. A. Conjugation - Alkyl-OH-glucuronidation 1 Human
Migalastat M4 PDM013874 N. A. Conjugation - Alkyl-OH-glucuronidation 1 Human
Migalastat M5 PDM013875 N. A. Conjugation - Sulfation of primary alcohol 1 Human
Migalastat M6 PDM013876 N. A. Conjugation - Sulfation of secondary alcohol 1 Human
Migalastat M7 PDM013877 N. A. Conjugation - Sulfation of secondary alcohol 1 Human
Migalastat M8 PDM013878 N. A. Conjugation - Sulfation of secondary alcohol 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
UDP-glucuronyltransferase (UGT) DMEN064 . Not Available Not Available [2]
References
1 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2 DrugBank(Pharmacology-Metabolism):Migalastat

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