Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000062)
Formula Reactant Adefovir Product Adefovir monophosphate
Reactant Info Product Info
Metabolic Enzyme Adenylate kinase isoenzyme 1 (AK1) DME Info
ATP-AMP transphosphorylase 2 (AK2) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011016 Adefovir Adefovir Dipivoxil Unclear - Unclear adefovir [1]
MR011014 Adefovir Cyclic prodrug of Adefovir 3 Unclear - Unclear adefovir [1]
MR002623 Adefovir Adefovir Dipivoxil(ADV-DP)2 Unclear ICN-2001-3 [1]
MR002619 Adefovir Cyclic prodrug of Adefovir 3 Unclear ICN-2001-3 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000063 Adefovir monophosphate Adefovir Diphosphate Other reaction - Phosphorylation Adefovir dipivoxil [2]
References
1 Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216.
2 Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells Biochem Pharmacol. 2004 Nov 1;68(9):1825-31. doi: 10.1016/j.bcp.2004.07.010.

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