Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000077)
Formula
ADA
SVG example
Deamination
Reactant Adenosine Product Inosine
Reactant Info Product Info
Metabolic Enzyme Adenosine aminohydrolase (ADA) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000076 Adenosine AMP Other reaction - Phosphorylation Adenosine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001474 Levocarnitine Inosine Oxidation - Deamination Levocarnitine [3]
MR002342 Tasimelteon Inosine Oxidation - Hydroxylation Tasimelteon [4]
MR000081 Adenosine phosphate metabolite IMP Inosine Unclear Adenosine phosphate [5], [2]
References
1 Adenosine Metabolism: Emerging Concepts for Cancer Therapy Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007.
2 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
3 Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. J Struct Biol. 2004 Jun;146(3):416-24.
4 Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11.
5 Condition-dependent adenosine monophosphate decomposition pathways in striated adductor muscle from Japanese scallop (Patinopecten yessoensis) J Food Sci. 2020 May;85(5):1462-1469. doi: 10.1111/1750-3841.15142.

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