Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000124)
Formula
SVG example
O-Demethylation
Reactant Alfentanil Product N-phenylpropionamide
Reactant Info Product Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000125 Alfentanil 2-(4-ethyl-5-oxo-1,2,3,4-tetrazol-1-yl)acetaldehyde Oxidation - N-Dealkylation Alfentanil [1]
MR000126 Alfentanil Alfentanil metabolite AM14 Oxidation - O-Demethylation Alfentanil [1]
MR000123 Alfentanil Alfentanil metabolite AM5 Oxidation - Oxidation Alfentanil [1]
MR000122 Alfentanil Noralfentanil Oxidation - N-Dealkylation Alfentanil [2]
References
1 Alfentanil pharmacokinetics and metabolism in humans Anesthesiology. 1988 Oct;69(4):527-34. doi: 10.1097/00000542-198810000-00012.
2 Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11.

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