Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000132)
Formula	O-Demethylation
	Reactant	Aliskiren	Product	Aliskiren metabolite M3
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - O-Demethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000134	Aliskiren	Aliskiren metabolite M1	Oxidation - O-Demethylation	Aliskiren	[1]
MR000136	Aliskiren	Aliskiren metabolite M12	Unclear	Aliskiren	[2]
MR000133	Aliskiren	Aliskiren metabolite M4	Oxidation - O-Dealkylation	Aliskiren	[1]
MR000135	Aliskiren	Aliskiren metabolite M9	Hydrolysis - Hydrolysis	Aliskiren	[2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000128	Aliskiren metabolite M3	Aliskiren metabolite M2	Oxidation - Oxidation	Aliskiren	[1]
MR000129	Aliskiren metabolite M3	Aliskiren metabolite M4	Oxidation - O-Dealkylation	Aliskiren	[1]

References
1	Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797.
2	U. S. FDA Label - Aliskiren

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