Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000151)
Formula Reactant LAS 31911 Product Almotriptan malate metabolite P13
Reactant Info Product Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000147 ACP-5461 LAS 31911 Other reaction - Dehydration Almotriptan malate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000150 LAS 31911 Almotriptan malate metabolite P5 Oxidation - Hydroxylation Almotriptan malate [2]
MR000149 LAS 31911 Almotriptan malate metabolite P6 Oxidation - N-Dealkylation Almotriptan malate [2]
MR000148 LAS 31911 Almotriptan malate metabolite P9 Oxidation - Hydroxylation Almotriptan malate [2]
References
1 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
2 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.

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