Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000156)
Formula Reactant Almotriptan malate Product Almotriptan malate metabolite M7
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase type A (MAO-A) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000152 Almotriptan malate Almotriptan malate metabolite M1 Oxidation - Oxidative Deamination Almotriptan malate [1]
MR000153 Almotriptan malate Almotriptan malate metabolite M3 Oxidation - Pyrrolidine Oxidation Almotriptan malate [1]
MR000155 Almotriptan malate LAS 31612 Oxidation - N-Demethylation Almotriptan malate [2], [1]
MR000154 Almotriptan malate LAS 32195 Oxidation - N-Oxidation Almotriptan malate [1]
References
1 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
2 Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11.

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