Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000178)
Formula Reactant Amlodipine besylate metabolite M10 Product Amlodipine besylate metabolite M12
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000173 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M10 Oxidation - Oxidative Deamination Amlodipine besylate [1]
MR000186 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M10 Oxidation - Oxidative Deamination Amlodipine maleate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000177 Amlodipine besylate metabolite M10 Amlodipine besylate metabolite H Unclear Amlodipine besylate [2]
MR000190 Amlodipine besylate metabolite M10 Amlodipine besylate metabolite H Unclear Amlodipine maleate [2]
References
1 Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.
2 Metabolism and kinetics of amlodipine in man Xenobiotica. 1988 Feb;18(2):245-54. doi: 10.3109/00498258809041660.

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