Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000180)
Formula Reactant Amlodipine besylate metabolite M1 Product Amlodipine besylate metabolite H
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000174 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M1 Oxidation - O-Demethylation Amlodipine besylate [1]
MR000187 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M1 Oxidation - O-Demethylation Amlodipine maleate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000176 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite H Unclear Amlodipine besylate [2]
MR000189 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite H Unclear Amlodipine maleate [2]
MR000177 Amlodipine besylate metabolite M10 Amlodipine besylate metabolite H Unclear Amlodipine besylate [2]
MR000190 Amlodipine besylate metabolite M10 Amlodipine besylate metabolite H Unclear Amlodipine maleate [2]
MR000179 Amlodipine besylate metabolite H Amlodipine besylate metabolite H Unclear Amlodipine besylate [2]
MR000192 Amlodipine besylate metabolite H Amlodipine besylate metabolite H Unclear Amlodipine maleate [2]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000179 Amlodipine besylate metabolite H Amlodipine besylate metabolite H Unclear Amlodipine besylate [2]
MR000192 Amlodipine besylate metabolite H Amlodipine besylate metabolite H Unclear Amlodipine maleate [2]
References
1 Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.
2 Metabolism and kinetics of amlodipine in man Xenobiotica. 1988 Feb;18(2):245-54. doi: 10.3109/00498258809041660.

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