Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000244)
Formula Reactant Apixaban M2 metabolite Product Apixaban M13 metabolite
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000248 Apixaban Apixaban M2 metabolite Oxidation - O-Demethylation Apixaban [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000245 Apixaban M2 metabolite Apixaban M1 metabolite Conjugation - Sulfation Apixaban [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000247 Apixaban M4/7 metabolite Apixaban M13 metabolite Oxidation - Hydroxylation Apixaban [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000246 Apixaban M13 metabolite Apixaban M10 metabolite Conjugation - Sulfation Apixaban [4]
References
1 Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509.
2 Apixaban. After hip or knee replacement: LMWH remains the standard treatment. Prescrire Int. 2012 Sep;21(130):201-2, 204.
3 Sulfation of o-demethyl apixaban: enzyme identification and species comparison. Drug Metab Dispos. 2009 Apr;37(4):802-8. doi: 10.1124/dmd.108.025593.
4 Apixaban metabolism and pharmacokinetics after oral administration to humans Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143.

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