Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000291)
Formula
SVG example
Esterase Hydrolysis
Reactant Aripiprazole lauroxil Product N-hydroxymethyl-aripiprazole
Reactant Info Product Info
Metabolic Type Hydrolysis - Esterase Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000292 Aripiprazole lauroxil Lauric acid Hydrolysis - Esterase Hydrolysis Aripiprazole lauroxil [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000288 N-hydroxymethyl-aripiprazole Aripiprazole Hydrolysis - Hydrolysis Aripiprazole lauroxil [1], [2]
MR000289 N-hydroxymethyl-aripiprazole Formaldehyde Hydrolysis - Hydrolysis Aripiprazole lauroxil [1], [2]
References
1 Aripiprazole Lauroxil: Pharmacokinetic Profile of This Long-Acting Injectable Antipsychotic in Persons With Schizophrenia J Clin Psychopharmacol. 2017 Jun;37(3):289-295. doi: 10.1097/JCP.0000000000000691.
2 Biological conversion of?aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug Results Pharma Sci. 2014 May 2;4:19-25. doi: 10.1016/j.rinphs.2014.04.002.

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