Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000367)
Formula Reactant GSH adduct Product Binimetinib metabolite M1
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000366 1,4-Diiminoquinone intermediate GSH adduct Unclear Binimetinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000368 GSH adduct Binimetinib metabolite M4 Unclear Binimetinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000369 Binimetinib metabolite M1 Binimetinib metabolite M2 Unclear Binimetinib [1]
MR000370 Binimetinib metabolite M1 Binimetinib metabolite M3 Unclear Binimetinib [1]
References
1 Binimetinib Is a Potent Reversible and Time-Dependent Inhibitor of Cytochrome P450 1A2 Chem Res Toxicol. 2021 Apr 19;34(4):1169-1174. doi: 10.1021/acs.chemrestox.1c00036.

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