Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000393)
Formula
SVG example
Hydrolysis
Reactant BMS-650032 Product Asunaprevir metabolite M2
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000392 BMS-650032 Asunaprevir metabolite M10 Hydrolysis - Hydrolysis BMS-650032 [1], [2]
MR000395 BMS-650032 Asunaprevir metabolite M15 Unclear BMS-650032 [1], [2]
MR000394 BMS-650032 Asunaprevir metabolite M3,5,7 Oxidation - Monohydroxylation BMS-650032 [1], [2]
MR000389 BMS-650032 Asunaprevir metabolite M6 Oxidation - O-Demethylation BMS-650032 [1], [2]
MR000390 BMS-650032 Asunaprevir metabolite M8 Oxidation - Hydroxylation BMS-650032 [1], [2]
MR000391 BMS-650032 BMS-798430 Reduction - Reduction BMS-650032 [1], [2]
References
1 Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir J Hum Genet. 2020 Jan;65(2):143-153. doi: 10.1038/s10038-019-0685-2.
2 DrugBank(Pharmacology-Metabolism)Asunaprevir

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.