Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000420)
Formula Reactant BPI-2009 Product BPI-2009 metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000421 BPI-2009 BPI-2009 metabolite M11 Oxidation - Hydroxylation BPI-2009 [1]
MR000419 BPI-2009 BPI-2009 metabolite M16 Reduction - Reduction BPI-2009 [1]
MR000422 BPI-2009 BPI-2009 metabolite M6 Oxidation - Oxidation BPI-2009 [1]
MR000423 BPI-2009 BPI-2009 metabolite M7 Oxidation - Oxidation BPI-2009 [1]
MR000424 BPI-2009 BPI-2009 metabolite M8 Oxidation - Oxidation BPI-2009 [1]
References
1 Metabolic pathway of icotinib in vitro: the differential roles of CYP3A4, CYP3A5, and CYP1A2 on potential pharmacokinetic drug-drug interaction. J Pharm Sci. 2018 Apr;107(4):979-983.

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