Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000549)
Formula
UGT1A9 ...
SVG example
O-Glucuronidation
Reactant Canagliflozin Product Canagliflozin metabolite M5
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000548 Canagliflozin Canagliflozin metabolite M7 Conjugation - O-Glucuronidation Canagliflozin [1]
MR000550 Canagliflozin Canagliflozin metabolite M9 Oxidation - Hydroxylation Canagliflozin [1]
References
1 Clinical Pharmacokinetic, Pharmacodynamic, and Drug-Drug Interaction Profile of Canagliflozin, a Sodium-Glucose Co-transporter 2 Inhibitor Clin Pharmacokinet. 2015 Oct;54(10):1027-41. doi: 10.1007/s40262-015-0285-z.

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