Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000552)
Formula
UGT1A1 ...
SVG example
N-Glucuronidation
Reactant Candesartan Product Candesartan N2-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000554 Candesartan cilexetil Candesartan Hydrolysis - Hydrolysis Candesartan cilexetil [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000551 Candesartan Candesartan O-glucuronide Conjugation - O-Glucuronidation Candesartan cilexetil [2]
MR000553 Candesartan O-Deethylated candesartan Oxidation - O-Deethylation Candesartan cilexetil [3]
References
1 Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1. Drug Metab Dispos. 2013 Nov;41(11):1888-95.
2 The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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