Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000588)
Formula
UGT
SVG example
Glucuronidation
Reactant Celecoxib Product Celecoxib glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000587 Celecoxib Hydroxycelecoxib Oxidation - Hydroxylation Celecoxib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000586 Carboxycelecoxib Celecoxib metabolite M1 Conjugation - Glucuronidation Celecoxib [2]
References
1 Celecoxib pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012 Apr;22(4):310-8.
2 Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:202-11. doi: 10.1016/j.jchromb.2015.07.026.

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