Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000624)
Formula
CYP3A4 ...
SVG example
Reactant Chloramphenicol Product Desmethylcerivastatin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000625 Chloramphenicol D-threo-2-amino-1-(p-nitrophenyl)-1,3-propanediol Unclear Chloramphenicol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000602 Cerivastatin sodium Desmethylcerivastatin Oxidation - Demethylation Cerivastatin sodium [2]
References
1 Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes. Antimicrob Agents Chemother. 2003 Nov;47(11):3464-9.
2 DrugBank(Pharmacology-Metabolism)Cerivastatin

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