Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000626)
Formula
SVG example
N-Dealkylation
Reactant (R)-chloroquine, N-desethyl Product N-bidesethylchloroquine
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000628 Chloroquine (R)-chloroquine, N-desethyl Oxidation - N-Dealkylation Chloroquine [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000627 N-bidesethylchloroquine 7-chloro-4-aminoquinoline Unclear Chloroquine [1]
References
1 Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements Clin Pharmacokinet. 1996 Oct;31(4):257-74. doi: 10.2165/00003088-199631040-00003.
2 Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters Curr Drug Metab. 2020;21(14):1127-1135. doi: 10.2174/1389200221999201208211537.
3 Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes. Arch Pharm Res. 2003 Aug;26(8):631-7.

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