Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000658)
Formula
CYP3A5 ...
SVG example
Reactant Cilostazol Product OPC-13213
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000657 Cilostazol OPC-13326 Unclear Cilostazol [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000656 OPC-13213 OPC-13213 Unclear Cilostazol [1], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000656 OPC-13213 OPC-13213 Unclear Cilostazol [1], [3]
References
1 Determination of cilostazol and its metabolites in human urine by high performance liquid chromatography J Pharm Biomed Anal. 2001 Jan;24(3):381-9. doi: 10.1016/s0731-7085(00)00426-x.
2 Characterization of human cytochrome p450 enzymes involved in the metabolism of cilostazol Drug Metab Dispos. 2007 Oct;35(10):1730-2. doi: 10.1124/dmd.107.016758.
3 Effects of CYP2C19 and CYP3A5 genetic polymorphisms on the pharmacokinetics of cilostazol and its active metabolites Eur J Clin Pharmacol. 2018 Nov;74(11):1417-1426. doi: 10.1007/s00228-018-2522-5.

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