Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000665)
Formula Reactant CKD-501 Product CKD-501 metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000667 CKD-501 . Unclear CKD-501 [1]
MR000663 CKD-501 CKD-501 metabolite M1 Oxidation - Demethylation CKD-501 [2]
MR000664 CKD-501 CKD-501 metabolite M2 Oxidation - N-Demethylation CKD-501 [2]
MR000666 CKD-501 CKD-501 metabolite M4 Oxidation - N-Oxidation CKD-501 [2]
References
1 Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats J Pharm Sci. 2015 Sep;104(9):3049-59. doi: 10.1002/jps.24378.
2 The identification of lobeglitazone metabolites in rat liver microsomes and the kinetics of the in vivo formation of the major metabolite M1 in rats J Pharm Biomed Anal. 2015 Nov 10;115:375-82. doi: 10.1016/j.jpba.2015.07.040.

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