Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000745)
Formula
SVG example
N-Oxidation
Reactant Dasatinib Product Dasatinib metabolite M5
Reactant Info Product Info
Metabolic Enzyme Dimethylaniline oxidase 3 (FMO3) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000747 Dasatinib Dasatinib metabolite M20 Oxidation - Hydroxylation Dasatinib [1]
MR000748 Dasatinib Dasatinib metabolite M24 Oxidation - Hydroxylation Dasatinib [1]
MR000744 Dasatinib Dasatinib metabolite M4 Oxidation - N-Dealkylation Dasatinib [1]
MR000746 Dasatinib Dasatinib metabolite M6 Unclear Dasatinib [1]
References
1 Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.

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