Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000767)
Formula Reactant 3-hydroxydesloratadine N-glucuronide Product 3-hydroxydesloratadine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000766 Desloratadine N-glucuronidation 3-hydroxydesloratadine N-glucuronide Oxidation - Hydroxylation Desloratadine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005248 Rupatadine 3-hydroxydesloratadine Unclear Rupatadine [3]
MR006902 Desloratadine glucuronide 3-Hydroxydesloratadine Oxidation - 3-hydroxylation Loratadine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006903 3-Hydroxydesloratadine 3-hydroxydesloratadine O-glucuronide Conjugation - Glucuronidation Loratadine [4]
MR000768 3-hydroxydesloratadine 3-hydroxydesloratadine O-glucuronide Conjugation - Glucuronidation Desloratadine [2]
References
1 Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302.
2 A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620.
3 CYP3A5*3 and MDR1 C3435T are influencing factors of inter-subject variability in rupatadine pharmacokinetics in healthy Chinese volunteers. Eur J Drug Metab Pharmacokinet. 2016 Apr;41(2):117-24.
4 Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story. Bioanalysis. 2016 Aug;8(16):1645-62.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.