Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000786)
Formula
SVG example
Reactant Deutetrabenazine Product D6alpha-dihydrotetrabenazine
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 3 (CBR3) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000787 Deutetrabenazine Cis (2,3)-Dihydro Tetrabenazine-d6 Unclear Deutetrabenazine [1]
MR000788 Deutetrabenazine Deutetrabenazine metabolite M4 Oxidation - Hydroxylation Deutetrabenazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000778 D6alpha-dihydrotetrabenazine D3-10-O-Desmethyl-Alpha-Htbz Oxidation - Demethylation Deutetrabenazine [1]
MR000777 D6alpha-dihydrotetrabenazine D3-9-O-Desmethyl-Alpha-Htbz Oxidation - Demethylation Deutetrabenazine [1]
References
1 Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers Clin Transl Sci. 2020 Jul;13(4):707-717. doi: 10.1111/cts.12754.

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