Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000805)
Formula
SVG example
Deesterification
Reactant Dexmethylphenidate Product Ritalinic acid
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase (CES1A1a) DME Info
Metabolic Type Other reaction - Deesterification
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000807 Dexmethylphenidate 6-oxo-methylphenidate Oxidation - Oxidation Dexmethylphenidate [1]
MR000806 Dexmethylphenidate p-hydroxy-methylphenidate Oxidation - Hydroxylation Dexmethylphenidate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013394 Methylphenidate Alpha-phenyl-2-piperidine acetic acid (ritalinic acid) Hydrolysis - Esterase hydrolyzation Methylphenidate [2], [3]
References
1 Pharmacokinetics and clinical effectiveness of methylphenidate Clin Pharmacokinet. 1999 Dec;37(6):457-70. doi: 10.2165/00003088-199937060-00002.
2 Metabolism of methylphenidate in dog and rat
3 Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76.

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