Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000847)
Formula
SVG example
Reactant Digitoxin Product Digoxin
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000842 Digitoxin Digitoxigenin Unclear Digitoxin [1]
MR000844 Digitoxin Digitoxigenin-bisdigitoxoside Oxidation - Oxidation Digitoxin [2], [3]
MR000845 Digitoxin Digitoxigenin-monodigitoxoside Oxidation - Oxidation Digitoxin [2]
MR000843 Digitoxin Dihydrodigitoxin Unclear Digitoxin [1]
MR000846 Digitoxin Epidigitoxigenin Unclear Digitoxin [4]
References
1 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760
2 Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin. Mol Pharmacol. 1991 Nov;40(5):859-67.
3 Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man. Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):226-33.
4 Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY:Elsevier Science Publishing Co., Inc. 1988., p. 201

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