Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000855)
Formula
SVG example
Cleavage
Reactant Digoxin Product Digoxigenin-bisdigitoxoside
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Cleavage
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000856 Digoxin Dihydrodigoxin Reduction - Reduction Digoxin [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000848 Digoxigenin-bisdigitoxoside Digoxigenin-monodigitoxoside Oxidation - Cleavage Digoxin [3]
References
1 Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8.
2 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511
3 Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A Xenobiotica. 1999 Feb;29(2):171-85. doi: 10.1080/004982599238722.

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