Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000863)
Formula Reactant N-monodesmethyl diltilazem Product Deacetyl N-monodesmethyl diltiazem
Reactant Info Product Info
Metabolic Enzyme Liver esterases (LE) DME Info
Metabolic Type Conjugation - Acetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000868 Diltiazem hydrochloride N-monodesmethyl diltilazem Oxidation - N-Demethylation Diltiazem hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000864 N-monodesmethyl diltilazem N,O-didesmethyl diltiazem Oxidation - O-Demethylation Diltiazem hydrochloride [2], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000865 Deacetyl N-monodesmethyl diltiazem Deacetyl N,O-didesmethyl diltiazem Oxidation - O-Demethylation Diltiazem hydrochloride [1]
References
1 Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug Metab Dispos. 2002 Jan;30(1):1-3.
2 Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.