Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000882)
Formula
SVG example
Oxidative Desulphurylation
Reactant Diethyldithiocarbamic acid methyl ester Product Diethylthiocarbamic acid methyl ester
Reactant Info Product Info
Metabolic Type Oxidation - Oxidative Desulphurylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000881 Diethyldlthiocarbamic acid Diethyldithiocarbamic acid methyl ester Unclear Disulfiram [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000883 Diethyldithiocarbamic acid methyl ester . Oxidation - Sulfoxidation Disulfiram [2]
References
1 Pharmacological effects of diethylthiocarbamic acid methyl ester, the active metabolite of disulfiram? Eur J Pharmacol. 1989 Aug 3;166(3):419-25. doi: 10.1016/0014-2999(89)90354-3.
2 Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation. Alcohol Clin Exp Res. 1998 Sep;22(6):1212-9.

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