Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000893)
Formula
SVG example
N-Oxidation
Reactant Dofetilide Product Dofetilide N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000894 Dofetilide Dofetilide metabolite M1 Hydrolysis - Hydrolysis Dofetilide [1]
MR000895 Dofetilide Dofetilide metabolite M2 Hydrolysis - Hydrolysis Dofetilide [1]
MR000892 Dofetilide N-desmethyl dofetllfde Oxidation - N-Dealkylation Dofetilide [1]
References
1 Dofetilide, a novel class III antiarrhythmic agent J Cardiovasc Pharmacol. 1992;20 Suppl 2:S96-105.

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