| General Information of This Metabolic Reaction (MR) (ID:
MR000900) |
| Formula |
Reactant |
Efavirenz metabolite M8 |
Product |
Efavirenz metabolite M14 |
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Reactant Info
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Product Info
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Metabolic Enzyme
|
UDP-glucuronyltransferase (UGT)
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DME Info
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Metabolic Type
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Conjugation
-
Conjugation
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| Other MR(s) Related to The Reactant of This MR |
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Other MR(s) That Produce The Reactant of This MR
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| References |
| 1 |
Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J Clin Pharmacol. 2004 Nov;44(11):1273-81.
|
| 2 |
Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
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| 3 |
Evaluation of CYP2B6 induction and prediction of clinical drug-drug interactions: considerations from the IQ consortium induction working group-an industry perspective. Drug Metab Dispos. 2016 Oct;44(10):1720-30.
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