Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000911)
Formula
SVG example
Hydroxylation
Reactant Epoprostenol Product 6,15-Diketo-13,14-dihydro-PGF1alpha
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000912 Epoprostenol 6-Keto-PGF1alpha Unclear Epoprostenol [1], [2]
References
1 Integrated pharmacokinetics and pharmacodynamics of epoprostenol in healthy subjects Br J Clin Pharmacol. 2012 Dec;74(6):978-89. doi: 10.1111/j.1365-2125.2012.04301.x.
2 In search of pulmonary hypertension treatments: Effect of 17-estradiol on PGI(2) pathway in human pulmonary artery. Prostaglandins Leukot Essent Fatty Acids. 2021 Sep;172:102321. doi: 10.1016/j.plefa.2021.102321.

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