Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000941)
Formula
SVG example
N-Demethylation
Reactant S-desmethylcitalopram Product S-didesmethylcitalopram
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000942 Escitalopram S-desmethylcitalopram Oxidation - N-Demethylation Escitalopram [1], [2]
References
1 PharmGKB summary: citalopram pharmacokinetics pathway. Pharmacogenet Genomics. 2011 Nov;21(11):769-72.
2 Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram Drug Metab Dispos. 2001 Aug;29(8):1102-9.

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