Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000956)
Formula
SVG example
5-Hydroxylation
Reactant Esomeprazole Product 5-hydroxyomeprazole
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 5-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000955 Esomeprazole 5-O-Desmethylomeprazole Oxidation - O-Dealkylation Esomeprazole [1]
MR000953 Esomeprazole Active metabolite of Esomeprazole Unclear Esomeprazole [2]
MR000954 Esomeprazole Omeprazole sulfone metabolite Oxidation - S-Oxidation Esomeprazole [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001830 Omeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Omeprazole [5]
References
1 Expression, activity and regulation of CYP3A in human and rodent brain Drug Metab Rev. 2008;40(1):149-68. doi: 10.1080/03602530701836712.
2 DrugBank(Pharmacology-Metabolism)Esomeprazole
3 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.
4 Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet. 2001;40(6):411-26. doi: 10.2165/00003088-200140060-00003.
5 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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